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What is the IOmics-OA study?

The Integrative Omics Center for Opioid Addiction Research (IOmics-OA) is a P50 Center of Excellence that assembles top genomics researchers from multiple institutions to conduct four interlocking studies aimed at identifying key biological drivers of opioid addiction (OA) and providing researchers nationwide with fundamental tools and knowledge needed to improve options for treating OA.

To overcome these challenges, IOmics-OA harnesses four Projects and a Synergy Core.
Project 1
Electronic Health Record Phenotyping and Genomics of Opioid Addiction
Project 2
Gene Regulation in the Opioid Dependent Human Brain
Project 3
Multi-species Approach to Opioid Addiction
Project 4
Cross-species Gene Network Identification, Integration and Analysis to Better Understand the Neurobiology of Opioid Addiction
Synergy Core
Multi-omic data integration and analysis core

Each Project is rigorously designed to make novel contributions. However, by integrating the diversity of IOmics-OA's science through the cross-pollination and coordination efforts of the Cores, we will leverage the agnostic discovery power of omics and place it within the context of functional neurobiology to make field-changing breakthroughs and identify actionable targets for development of OA treatments.

Why is this study important?

Opioid addiction (OA) is a deadly public health burden in the United States and across the globe that continues to worsen. We still lack a clear understanding of why some people are more likely to become addicted than others, but it is clear that genetic variation is a primary driver.

To address this knowledge gap, IOmics-OA will

  1. Conduct large-scale integrated multi-omics studies of OA in humans
  2. Integrate rodent and human studies to identify genes and gene networks implicated in OA
  3. Build a publicly available national omics resource for studying OA

Additional information

Opioid addiction resources
Network information
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